Ching-Chyuan Hsieh, Ph.D., Professor
My main research activity is involved in the Aging Program Project. Using rodents as a model, we studied the effects of aging on the expression of transcription factors that mediate the expression of genes involved in acute phase response. Three transcription factors: C/EBP, NFkB, and AP-1 are our focus of interest in these studies. One of our goals is to understand the molecular mechanism, which mediate the regulation of these transcription factors and how aging is involved in this process. The second goal is to identify and characterize the signaling pathways that are involved in the regulation of these transcription factors and the role aging plays in these signaling pathways. Another aspect of the studies is to investigate the molecular mechanism that oxidative stress plays in the aging process and the signaling pathways that are targeted by oxidative stress and aging. The second phase of our studies is to use dwarf mice (Snell and Ames dwarf mice) as a model system to study the genetic of aging, in an attempt to identify the factors and signaling pathways (particularly, the growth hormone/insulin-like growth factor pathway) involved in the longevity of these mice. We also studied the effects of diet-restriction on the process of aging by examining the expression of transcription factors and acute response genes, as well as the signaling pathways involved, in the livers of these diet-restriction mice.