Scott Silva

Lab:

B. Mark Evers

In BMB since (year):

2007

Biographical Information:

• Undergraduate institution: The University of Texas at Austin
• Undergraduate degree: B.S., Biochemistry with Highest Honors

Research interests:

Carcinoid tumors are neuroendocrine tumors of the gastrointestinal tract that secrete various amines and peptide products, such as serotonin, chromogranin A, and neurotensin. One of the unfortunate aspects of this disease is that because carcinoids are slow growing tumors, the disease is usually not detected until after the development of metastases. In the late stage of the disease, patients may experience a set of symptoms, collectively known as the carcinoid syndrome, which includes flushing and heart failure (due to cardiac valve fibrosis). I am interested in using in vitro and in vivo models of carcinoid to further delineate the mechanisms of carcinoid metastasis and carcinoid syndrome.

Interests outside of the lab:

When I am not studying or doing experiments, I enjoy playing guitar, racquetball, and ultimate frisbee.

Random facts about me:

I was born and raised in Palm Desert, California. I moved to the Dallas area in high school and later attended The University of Texas at Austin. In 2005 I entered the MD/PhD Program at UTMB.

Grants/Awards:

• 2005 - Phi Beta Kappa
• 2007 - Phi Kappa Phi
• 2007 - Margaret Saunders Travel Scholarship Award
• 2008 - American Cancer Society Institutional Research Grant
• 2008 - Marianne Blum, Ph.D. Endowed Scholarship

Publications/Posters:

1. TARGETED MOLECULAR THERAPY OF THE PI3K PATHWAY: THERAPEUTIC SIGNIFICANCE OF PI3K SUBUNIT TARGETING IN COLORECTAL CARCINOMA, Piotr G. Rychahou, MD, Lindsey N. Jackson, MD, Scott R. Silva, BS, Srinivasan Rajaraman, MD, B. Mark Evers, Annals of Surgery, 243 (6): 833-844, June 2006
2. PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy, Lindsey N. Jackson, Shawn D. Larson, Scott R. Silva, Piotr G. Rychahou, L. Andy Chen, Suimin Qiu, Srinivasan Rajaraman, B. Mark Evers, American Journal of Physiology - Gastrointestinal and Liver Physiology, 294 (6): G1401-G1410, June 2008
3. PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion, L. Andy Chen, Jing Li, Scott R. Silva, Lindsey N. Jackson, Yuning Zhou, Hiroaki Watanabe, Kirk L. Ives, Mark R. Hellmich, B. Mark Evers, Journal of Biological Chemistry, 284 (4): 2459-2471, January 23, 2009
4. DEVELOPMENT AND CHARACTERIZATION OF A NOVEL IN VIVO MODEL OF CARCINOID SYNDROME, Lindsey N. Jackson, L. Andy Chen, Shawn D. Larson, Scott R. Silva, Piotr G. Rychahou, Paul J. Boor, Jing Li, Gilberto DeFreitas, W. Lane Stafford, Courtney M. Townsend, Jr., B. Mark Evers, Clinical Cancer Research, 15 (8): April 15, 2009