Shelton S. Bradrick, PhDAssistant Professor

Dr. Shelton Bradrick

Department of Biochemistry & Molecular Biology

Route: 1055 | Tel: (409) 772-2749 | ssbradri@utmb.edu

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Education and Training

BS in Biotechnology, University of Nebraska-Omaha
PhD in Pathology and Microbiology, University of Nebraska Medical Center
Post-Doctoral in Molecular Genetics and Microbiology, Duke University

I earned my Ph.D. at the University of Nebraska studying the pathological consequences of coxsackievirus B3 infection of heart tissue and conducted postdoctoral research at Duke University on host-pathogen interactions involving hepatitis C virus. I am currently interested in pathogenic human flaviviruses and the impact of RNA biology of inflammation. In collaboration with Dr. Mariano Garcia-Blanco, our laboratory is pursuing projects involving molecular host-pathogen interactions for several arthropod-borne flaviviruses, including Dengue virus, Zika and Yellow Fever viruses (YFV). Replication of these positive-strand RNA viruses is dependent on, or restricted by, host-encoded RNA and protein factors. We are particularly interested in the identification and characterization of RNA-protein interactions that regulate viral replication and host gene expression. Specific projects include: (i) elucidating the role of particular ribosomal proteins in flavivirus and cellular translation regulation, (ii) roles for RNA-binding proteins in different phases of the flavivirus life-cycle, and (iii) the RNA biology of inflammatory diseases with particular emphasis on Multiple Sclerosis.