Human and insect host factors
important for flaviviruses.
Flaviviruses are a major health problem in the tropics and represent an emerging danger to global health. Previous work from the laboratory employed en masse approached to identify host factors, both insect and human, that impact infection by pathogenic flaviviruses. Some of these are pro-viral factors required for efficient viral replication, while others are antiviral factors, which limit infectivity and are part of the host defense against viral pathogens.